Name | Pneumocandin B0 |
Synonyms | CS-492 Pneumocardin B0 Pneumocandin B0 pneumocandin B(0) B0 PneuMocandin B0 pneumocandins? Impurity Pneumocandin B0 (L-688786) |
CAS | 135575-42-7 |
EINECS | 629-746-0 |
InChI | InChI=1/C50H80N8O17/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(66)52-31-22-35(64)46(71)56-48(73)41-33(62)18-19-57(41)50(75)39(34(63)23-36(51)65)54-47(72)40(43(68)42(67)28-14-16-29(60)17-15-28)55-45(70)32-21-30(61)24-58(32)49(74)38(27(4)59)53-44(31)69/h14-17,25-27,30-35,38-43,46,59-64,67-68,71H,5-13,18-24H2,1-4H3,(H2,51,65)(H,52,66)(H,53,69)(H,54,72)(H,55,70)(H,56,73)/t25?,26?,27-,30+,31-,32-,33-,34-,35+,38-,39-,40-,41-,42-,43-,46+/m0/s1 |
Molecular Formula | C50H80N8O17 |
Molar Mass | 1065.21 |
Density | 1.41±0.1 g/cm3(Predicted) |
Melting Point | >230°C (dec.) |
Boling Point | 1442.9±65.0 °C(Predicted) |
Flash Point | 826.5°C |
Solubility | DMSO (Slightly), Methanol (Sparingly) |
Vapor Presure | 0mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
Maximum wavelength(λmax) | ['276nm(MeOH)(lit.)'] |
pKa | 9.86±0.26(Predicted) |
Storage Condition | Sealed in dry,Store in freezer, under -20°C |
Refractive Index | 1.629 |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0.939 ml | 4.694 ml | 9.388 ml |
5 mM | 0.188 ml | 0.939 ml | 1.878 ml |
10 mM | 0.094 ml | 0.469 ml | 0.939 ml |
5 mM | 0.019 ml | 0.094 ml | 0.188 ml |
introduction | numocandin (Pneumocandins)B0 is a natural antifungal drug produced by Zalerion arboricola. it has a cyclic hexapeptide nucleus and a fatty acid side chain structure. because it is effective against a variety of candida, endemic fungi, aspergillus and pneumocystis carinii, it has attracted more and more attention. The cyclic hexapeptide nucleus after removing the fatty acid side chain of Numoconidine B0 is the main raw material for the synthesis of caspofungin (Caspofungin). |
Mechanism of Action | Numocandin B0 is an antifungal lipopeptide and an effective antifungal agent. It inhibits the basic component of the cell wall of sensitive fungi. β-(1,3)-D-glucan produces action. It works by inhibiting the synthesis of β-(1,3)-D-glucan, a component of the fungal cell wall (IC 50=70 and 67ng / ml for inhibiting glucan synthase and A 1 in Candida albicans) can be used to synthesize caspofungin acetate. |
application | newmoconidine B0 can be used as a scientific research reagent and is widely used in molecular biology, pharmacology and other scientific research. |
biological activity | Pneumocandin B0(L-688786) is a synthetic intermediate of Cancidas. |